Structure and formation of microplasmin.

H. L. Wu, G. Y. Shi, R. C. Wohl, M. L. Bender

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48 引文 斯高帕斯(Scopus)

摘要

The structure of human microplasmin, prepared from plasmin in alkaline solution, has been studied. Microplasmin consists of two polypeptide chains connected by disulfide bonds. One polypeptide is the B chain of plasmin consisting of 230 amino acids, and the other peptide is the COOH-terminal portion of the A chain of plasmin consisting of 31 amino acid residues. Microplasmin has a molecular weight of 28,635, calculated from its primary sequence. It is slightly more positively charged than plasminogen and is a more hydrophobic molecule. The proposed scheme for the formation of microplasmin involves autolysis at specific peptide bonds and scrambling of especially sensitive disulfide bonds in alkaline solution.

原文English
頁(從 - 到)8793-8795
頁數3
期刊Proceedings of the National Academy of Sciences of the United States of America
84
發行號24
DOIs
出版狀態Published - 1987 十二月

All Science Journal Classification (ASJC) codes

  • 多學科

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