Studies of magnetic alginate-based electrospun matrices crosslinked with different methods for potential hyperthermia treatment

Yen Hsuan Chen, Chi Hui Cheng, Wan Ju Chang, Yi Ching Lin, Feng Huei Lin, Jui Che Lin

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

The magnetic electrospun mats were lately established as an innovative biomaterial for hyperthermic cancer treatment. Unlike those surface-modified magnetic nanoparticles that may not firmly adhere onto the tumor for long-term duration, the magnetic mats with nanofibrous structure can promote cell adhesion and kill the tumor directly within an alternating magnetic field. However, most magnetic electrospun mats were fabricated using non-biodegradable polymers and organic solvents, causing the problems of removal after therapy and the suspected biotoxicity associated with residual solvent. Alginate (SA) was utilized in this investigation as the main material for electrospinning because of being biodegradable and water-soluble. The alginate-based electrospun mats were then treated by an ionic or a covalent crosslinking method, and then followed by chelation with Fe2 +/Fe3 + for chemical coprecipitation of Fe3O4 magnetic nanoparticles. Significant less cytotoxicity was noted on both liquid extracts from the ionic-crosslinked (Fe3O4-SA/PEO) and covalent-crosslinked (Fe3O4-SA/PVA) magnetic electrospun mats as well as the surface of Fe3O4-SA/PVA. In vitro hyperthermia assay indicated that the covalent-crosslinked magnetic alginate-based mats reduced tumor cell viability greater than Fe3O4 nanoparticles. Such magnetic electrospun mats are of potential for hyperthermia treatment by endoscopic/surgical delivery as well as serving as a supplementary debridement treatment after surgical tumor removal.

原文English
頁(從 - 到)338-349
頁數12
期刊Materials Science and Engineering C
62
DOIs
出版狀態Published - 2016 五月 1

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)
  • 凝聚態物理學
  • 材料力學
  • 機械工業

指紋

深入研究「Studies of magnetic alginate-based electrospun matrices crosslinked with different methods for potential hyperthermia treatment」主題。共同形成了獨特的指紋。

引用此