Creating a surface with anti- or reduced fouling characteristics can lead to a reduction in nonspecific protein adsorption as well as the bacterial adhesion and platelet adhesion/activation that occur as follows. A zwitterionic polymer that consists of both cationic and anionic functionalities have been reported as an effective material to achieve these goals, likely resulted from the strongly-adsorbed hydration layer after being immersed in the physiological environment. In this investigation, a novel beta-thiopropionate-based zwitterionic monomer, 2-ammonio-3-((3-(2-hydroxy-3-(methacryloyloxy)propoxy)-3-oxopropyl)thio)-3-methylbutanoate (DPAMA), was synthesized through a facial process. And then the hydrophobic polypropylene was surface modified with this novel zwitterionic polymer through the surface-initiated atom transfer radical polymerization technique. Surface characterization analyses have been employed to investigate the modified surface properties in each reaction stage. In vitro protein adsorption, bacterial adhesion, and platelet compatibility evaluations have shown the polyDPAMA-modified polypropylene surface has significantly reduced fouling characteristics and good hemocompatibility. Henceforth, this novel zwitterionic polyDPAMA grafting PP and the associated grafting reaction scheme have great potential for future clinical applications.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering