Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Wei Ren Chen; Pei Yu Huang; Chien Wen Wang; Yi Dong Lin; Chi Chang Lin; Hsien Chang Chang

doi:10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Wei Ren Chen
, Pei Yu Huang
, Chien Wen Wang
, Yi Dong Lin
, Chi Chang Lin
, Hsien Chang Chang

生物醫學工程學系

研究成果: Conference contribution

摘要

According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

原文	English
主出版物標題	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
頁面	1129-1132
頁數	4
DOIs	https://doi.org/10.1109/NEMS.2007.352216
出版狀態	Published - 2007
事件	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand 持續時間: 2007 1月 16 → 2007 1月 19

出版系列

名字	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
國家/地區	Thailand
城市	Bangkok
期間	07-01-16 → 07-01-19

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

All Science Journal Classification (ASJC) codes

電腦網路與通信
電腦科學應用
電氣與電子工程

存取文件

10.1109/NEMS.2007.352216

其它文件與鏈接

引用此

Chen, W. R., Huang, P. Y., Wang, C. W., Lin, Y. D., Lin, C. C., & Chang, H. C. (2007). Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. 於 Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (頁 1129-1132). 文章 4160519 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352216

Chen, Wei Ren ; Huang, Pei Yu ; Wang, Chien Wen 等. / Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. 頁 1129-1132 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

@inproceedings{daa9168b8a664d76bc7f316a773f7d75,

title = "Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays",

abstract = "According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.",

author = "Chen, \{Wei Ren\} and Huang, \{Pei Yu\} and Wang, \{Chien Wen\} and Lin, \{Yi Dong\} and Lin, \{Chi Chang\} and Chang, \{Hsien Chang\}",

year = "2007",

doi = "10.1109/NEMS.2007.352216",

language = "English",

isbn = "1424406102",

series = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

pages = "1129--1132",

booktitle = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

note = "2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 ; Conference date: 16-01-2007 Through 19-01-2007",

}

Chen, WR, Huang, PY, Wang, CW, Lin, YD, Lin, CC & Chang, HC 2007, Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. 於 Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160519, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, 頁 1129-1132, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 07-01-16. https://doi.org/10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. / Chen, Wei Ren; Huang, Pei Yu; Wang, Chien Wen 等.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1129-1132 4160519 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

研究成果: Conference contribution

TY - GEN

T1 - Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

AU - Chen, Wei Ren

AU - Huang, Pei Yu

AU - Wang, Chien Wen

AU - Lin, Yi Dong

AU - Lin, Chi Chang

AU - Chang, Hsien Chang

PY - 2007

Y1 - 2007

N2 - According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

AB - According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

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UR - https://www.scopus.com/pages/publications/34548126833#tab=citedBy

U2 - 10.1109/NEMS.2007.352216

DO - 10.1109/NEMS.2007.352216

M3 - Conference contribution

AN - SCOPUS:34548126833

SN - 1424406102

SN - 9781424406104

T3 - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

SP - 1129

EP - 1132

BT - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

T2 - 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Y2 - 16 January 2007 through 19 January 2007

ER -

Chen WR, Huang PY, Wang CW, Lin YD, Lin CC, Chang HC. Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. 於 Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1129-1132. 4160519. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). doi: 10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

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All Science Journal Classification (ASJC) codes

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