Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats

Ching-Hsia Hung, Ja Ping Shieh, Chong Chi Chiu, Jhi Joung Wang, Yu Wen Chen

研究成果: Article

1 引文 (Scopus)

摘要

Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED 50 )), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED 25 , ED 50 and ED 75 ), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.

原文English
頁(從 - 到)565-569
頁數5
期刊Pharmacological Reports
70
發行號3
DOIs
出版狀態Published - 2018 六月 1

指紋

Doxylamine
Bupivacaine
Analgesia
Skin
Analgesics
Local Anesthetics
Histamine Antagonists
Subcutaneous Injections
Reflex

All Science Journal Classification (ASJC) codes

  • Pharmacology

引用此文

Hung, Ching-Hsia ; Shieh, Ja Ping ; Chiu, Chong Chi ; Wang, Jhi Joung ; Chen, Yu Wen. / Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. 於: Pharmacological Reports. 2018 ; 卷 70, 編號 3. 頁 565-569.
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Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. / Hung, Ching-Hsia; Shieh, Ja Ping; Chiu, Chong Chi; Wang, Jhi Joung; Chen, Yu Wen.

於: Pharmacological Reports, 卷 70, 編號 3, 01.06.2018, p. 565-569.

研究成果: Article

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AU - Chen, Yu Wen

PY - 2018/6/1

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N2 - Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED 50 )), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED 25 , ED 50 and ED 75 ), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.

AB - Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED 50 )), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED 25 , ED 50 and ED 75 ), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.

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