Subcutaneous l-tyrosine elicits cutaneous analgesia in response to local skin pinprick in rats

Ching Hsia Hung, Chong Chi Chiu, Kuo Sheng Liu, Yu Wen Chen, Jhi Joung Wang

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

The purpose of the study was to estimate the ability of l-tyrosine to induce cutaneous analgesia and to investigate the interaction between l-tyrosine and the local anesthetic lidocaine. After subcutaneously injecting the rats with l-tyrosine and lidocaine in a dose-dependent manner, cutaneous analgesia (by blocking the cutaneous trunci muscle reflex-CTMR) was evaluated in response to the local pinprick. The drug-drug interaction was analyzed by using an isobolographic method. We showed that both l-tyrosine and lidocaine produced dose-dependent cutaneous analgesia. On the 50% effective dose (ED50) basis, the rank of drug potency was lidocaine (5.09 [4.88-5.38] μmol)>l-tyrosine (39.1 [36.5-41.8] μmol) (P<0.05). At the equipotent doses (ED25, ED50, and ED75), the duration of cutaneous analgesia caused by l-tyrosine lasted longer than that caused by lidocaine (P<0.01). Lidocaine co-administered with l-tyrosine exhibited an additive effect on infiltrative cutaneous analgesia. Our pre-clinical study demonstrated that l-tyrosine elicits the local/cutaneous analgesia, and the interaction between l-tyrosine and lidocaine is additive. l-tyrosine has a lower potency but much greater duration of cutaneous analgesia than lidocaine. Adding l-tyrosine to lidocaine preparations showed greater duration of cutaneous analgesia compared with lidocaine alone.

原文English
頁(從 - 到)457-462
頁數6
期刊European Journal of Pharmacology
765
DOIs
出版狀態Published - 2015 10月 15

All Science Journal Classification (ASJC) codes

  • 藥理

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