Subject-specific multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer’s disease

Liwei Guo, John C. Vardakis, Toni Lassila, Micaela Mitolo, Nishant Ravikumar, Dean Chou, Matthias Lange, Ali Sarrami-Foroushani, Brett J. Tully, Zeike A. Taylor, Susheel Varma, Annalena Venneri, Alejandro F. Frangi, Yiannis Ventikos

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27 引文 斯高帕斯(Scopus)

摘要

There is emerging evidence suggesting that Alzheimer’s disease is a vascular disorder, caused by impaired cerebral perfusion, which may be promoted by cardiovascular risk factors that are strongly influenced by lifestyle. In order to develop an understanding of the exact nature of such a hypothesis, a biomechanical understanding of the influence of lifestyle factors is pursued. An extended poroelastic model of perfused parenchymal tissue coupled with separate workflows concerning subject-specific meshes, permeability tensor maps and cerebral blood flow variability is used. The subject-specific datasets used in the modelling of this paper were collected as part of prospective data collection. Two cases were simulated involving male, non-smokers (control and mild cognitive impairment (MCI) case) during two states of activity (high and low). Results showed a marginally reduced clearance of cerebrospinal fluid (CSF)/interstitial fluid (ISF), elevated parenchymal tissue displacement and CSF/ISF accumulation and drainage in the MCI case. The peak perfusion remained at 8 mm s-1 between the two cases.

原文English
文章編號20170019
期刊Interface Focus
8
發行號1
DOIs
出版狀態Published - 2018 2月 6

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 生物物理學
  • 生物工程
  • 生物化學
  • 生物材料
  • 生物醫學工程

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