摘要
Background. Pancreatic fistula is still the major postoperative morbidity after distal pancreatectomy (DP). An inductive heat technology via needle arrays in a system of alternating magnetic fields (AMFs) was designed to seal off the pancreatic end. Methods. Twenty Lanyu pigs were divided into 2 groups for DP: the conventional group had hand-sewn closure of the pancreatic end (n = 10), and the AMF group received thermal DP by AMF (n = 10). Pathological examinations of the resected and remnant pancreas were studied immediately after resection and on the 14th postoperative day (POD), respectively. The severity and the incidence of pancreatic abscess were compared. Results. The incidence and severity of pancreatic abscess were significantly decreased in the AMF group than those in the conventional group (P =.009). In the immediate postoperative period, microscopic examination of the pancreatic resected end showed prominent coagulative necrosis, loss of NADPH-diaphorase activity, and significant apoptosis at the resected pancreas in the AMF group compared with the control group. Fourteen days after AMF ablation, the pancreatic stump end was covered with thick fibrosis, and histological study of the remnant pancreas showed that the parenchyma had well recovered with positive NADPH-diaphorase activity, and the pancreatic duct was sealed off successfully by prominent periductal fibrosis and intraductal plug. The body weight gain on the 14th POD was significantly increased in the AMF group (from 23.8 ± 1.8 kg to 25.4 ± 5.5 kg) compared with the conventional group (from 25.3 ± 2.1 to 25.4 ± 6.0 kg; P =.003). Conclusions. Inductive heats by the AMF system via needle array can be performed easily and can seal the pancreatic cut surface well during DP.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 150-157 |
| 頁數 | 8 |
| 期刊 | Surgical Innovation |
| 卷 | 20 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | Published - 2013 四月 1 |
指紋
All Science Journal Classification (ASJC) codes
- Surgery
引用此文
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Successfully seal pancreatic end after thermal distal pancreatectomy using needle arrays in alternating electromagnetic fields. / Chao, Ying Jui; Shan, Yan Shen; Zuchini, Roberto; Tsai, Hung Wen; Lin, Pin Wen; Lee, Gwo Bin; Lin, Xi Zhang.
於: Surgical Innovation, 卷 20, 編號 2, 01.04.2013, p. 150-157.研究成果: Article
TY - JOUR
T1 - Successfully seal pancreatic end after thermal distal pancreatectomy using needle arrays in alternating electromagnetic fields
AU - Chao, Ying Jui
AU - Shan, Yan Shen
AU - Zuchini, Roberto
AU - Tsai, Hung Wen
AU - Lin, Pin Wen
AU - Lee, Gwo Bin
AU - Lin, Xi Zhang
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Background. Pancreatic fistula is still the major postoperative morbidity after distal pancreatectomy (DP). An inductive heat technology via needle arrays in a system of alternating magnetic fields (AMFs) was designed to seal off the pancreatic end. Methods. Twenty Lanyu pigs were divided into 2 groups for DP: the conventional group had hand-sewn closure of the pancreatic end (n = 10), and the AMF group received thermal DP by AMF (n = 10). Pathological examinations of the resected and remnant pancreas were studied immediately after resection and on the 14th postoperative day (POD), respectively. The severity and the incidence of pancreatic abscess were compared. Results. The incidence and severity of pancreatic abscess were significantly decreased in the AMF group than those in the conventional group (P =.009). In the immediate postoperative period, microscopic examination of the pancreatic resected end showed prominent coagulative necrosis, loss of NADPH-diaphorase activity, and significant apoptosis at the resected pancreas in the AMF group compared with the control group. Fourteen days after AMF ablation, the pancreatic stump end was covered with thick fibrosis, and histological study of the remnant pancreas showed that the parenchyma had well recovered with positive NADPH-diaphorase activity, and the pancreatic duct was sealed off successfully by prominent periductal fibrosis and intraductal plug. The body weight gain on the 14th POD was significantly increased in the AMF group (from 23.8 ± 1.8 kg to 25.4 ± 5.5 kg) compared with the conventional group (from 25.3 ± 2.1 to 25.4 ± 6.0 kg; P =.003). Conclusions. Inductive heats by the AMF system via needle array can be performed easily and can seal the pancreatic cut surface well during DP.
AB - Background. Pancreatic fistula is still the major postoperative morbidity after distal pancreatectomy (DP). An inductive heat technology via needle arrays in a system of alternating magnetic fields (AMFs) was designed to seal off the pancreatic end. Methods. Twenty Lanyu pigs were divided into 2 groups for DP: the conventional group had hand-sewn closure of the pancreatic end (n = 10), and the AMF group received thermal DP by AMF (n = 10). Pathological examinations of the resected and remnant pancreas were studied immediately after resection and on the 14th postoperative day (POD), respectively. The severity and the incidence of pancreatic abscess were compared. Results. The incidence and severity of pancreatic abscess were significantly decreased in the AMF group than those in the conventional group (P =.009). In the immediate postoperative period, microscopic examination of the pancreatic resected end showed prominent coagulative necrosis, loss of NADPH-diaphorase activity, and significant apoptosis at the resected pancreas in the AMF group compared with the control group. Fourteen days after AMF ablation, the pancreatic stump end was covered with thick fibrosis, and histological study of the remnant pancreas showed that the parenchyma had well recovered with positive NADPH-diaphorase activity, and the pancreatic duct was sealed off successfully by prominent periductal fibrosis and intraductal plug. The body weight gain on the 14th POD was significantly increased in the AMF group (from 23.8 ± 1.8 kg to 25.4 ± 5.5 kg) compared with the conventional group (from 25.3 ± 2.1 to 25.4 ± 6.0 kg; P =.003). Conclusions. Inductive heats by the AMF system via needle array can be performed easily and can seal the pancreatic cut surface well during DP.
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UR - http://www.scopus.com/inward/citedby.url?scp=84875519808&partnerID=8YFLogxK
U2 - 10.1177/1553350612445640
DO - 10.1177/1553350612445640
M3 - Article
C2 - 22549905
AN - SCOPUS:84875519808
VL - 20
SP - 150
EP - 157
JO - Surgical Innovation
JF - Surgical Innovation
SN - 1553-3506
IS - 2
ER -