Sunshine-exposure variation of human striatal dopamine D2/D3 receptor availability in healthy volunteers

研究成果: Article

22 引文 斯高帕斯(Scopus)

摘要

Background: In addition to the serotonergic system, the central dopaminergic system has been reported to be correlated with seasonality. The aim of this study was to explore the difference in striatal dopamine D2/D3 receptor availability between healthy volunteers who had a high-sunshine exposure and those who had a low exposure. Methods: Sixty-eight participants were enrolled, and those in the upper and lower quartiles in terms of sunshine exposure were categorized into high- (n=17) and low-sunshine-exposure (n=18) subgroups. Single photon emission computed tomography with [123I] iodo-benzamide was used to measure striatal dopamine D2/D3 receptor availability. Results: Striatal dopamine D2/D3 receptor availability was significantly greater in the subjects with high-sunshine exposure than in those with low-sunshine exposure (F=7.97, p=0.01) after controlling for age, sex, and smoking status. Limitations: Different subjects were examined at different time points in our study. In addition, the sex and tobacco use distributions differed between groups. Conclusion: The central dopaminergic system may play a role in the neurobiological characteristics of sunshine-exposure variation.

原文English
頁(從 - 到)107-110
頁數4
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
35
發行號1
DOIs
出版狀態Published - 2011 一月 15

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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