13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy

Bor Shyang Sheu, Shui Cheng Lee, Pin Wen Lin, Shan Tair Wang, Yuh Chung Chang, Hsiao Bai Yang, Chiao Hsiung Chuang, Xi Zhang Lin

研究成果: Article

29 引文 (Scopus)

摘要

Background: This study was conducted to determine (1) whether Helicobacter pylori infection decreases in conjunction with time elapsed after gastrectomy and (2) the diagnostic efficacy of 13C urea breath test (UBT) for H pylori in patients after gastrectomy. Methods: From January 1997 to June 1998, 86 patients who had undergone gastrectomy and 180 patients with dyspepsia without gastrectomy were enrolled. A UBT for the analysis of excess 13CO2/12CO2 ratio (ECR) was obtained for each patient. Each patient also underwent endoscopy to obtain gastric biopsies for histology and H pylori culture. The presence of H pylori by either histology or culture served as the standard to test the efficacy of UBT. The 86 patients with a prior gastrectomy were categorized into 3 subgroups (I, less than 1 year; II, 1 to 3 years; III, greater than 3 years), according to the interval between surgery and UBT. The initial H pylori status of these 86 patients was determined by histologic evaluation of the resected stomach. Results: M trial initiation, the postgastrectomy group had a lower H pylori infection rate (52.3%) as compared with the dyspeptic control group (80%). The initial H pylori status among subgroups I, II, and III was similar. There was a trend for the presence of H pylori in the stomach to decrease with increasing time elapsed after surgery (I to III: 68.8%, 48.3%, 36%, respectively; p < 0.05). The maximum UBT sensitivity and specificity achieved were 82.2% and 87.8% in the gastrectomy group and 97.2% and 96.3% in the dyspeptic group, with cutoff points of 2.5 and 4.0, respectively. Conclusion: The prevalence of H pylori diminishes with time elapsed after gastrectomy. UBT for detection of H pylori is more effective in patients without prior gastrectomy than in patients who have undergone gastrectomy and is less effective than endoscopy for patients who have had a gastrectomy.

原文English
頁(從 - 到)670-675
頁數6
期刊Gastrointestinal Endoscopy
51
發行號6
DOIs
出版狀態Published - 2000 一月 1

指紋

Breath Tests
Gastrectomy
Pylorus
Helicobacter pylori
Endoscopy
Urea
Stomach
Histology
Dyspepsia
Helicobacter Infections
Biopsy
Sensitivity and Specificity
Control Groups

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

引用此文

Sheu, Bor Shyang ; Lee, Shui Cheng ; Lin, Pin Wen ; Wang, Shan Tair ; Chang, Yuh Chung ; Yang, Hsiao Bai ; Chuang, Chiao Hsiung ; Lin, Xi Zhang. / 13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy. 於: Gastrointestinal Endoscopy. 2000 ; 卷 51, 編號 6. 頁 670-675.
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title = "13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy",
abstract = "Background: This study was conducted to determine (1) whether Helicobacter pylori infection decreases in conjunction with time elapsed after gastrectomy and (2) the diagnostic efficacy of 13C urea breath test (UBT) for H pylori in patients after gastrectomy. Methods: From January 1997 to June 1998, 86 patients who had undergone gastrectomy and 180 patients with dyspepsia without gastrectomy were enrolled. A UBT for the analysis of excess 13CO2/12CO2 ratio (ECR) was obtained for each patient. Each patient also underwent endoscopy to obtain gastric biopsies for histology and H pylori culture. The presence of H pylori by either histology or culture served as the standard to test the efficacy of UBT. The 86 patients with a prior gastrectomy were categorized into 3 subgroups (I, less than 1 year; II, 1 to 3 years; III, greater than 3 years), according to the interval between surgery and UBT. The initial H pylori status of these 86 patients was determined by histologic evaluation of the resected stomach. Results: M trial initiation, the postgastrectomy group had a lower H pylori infection rate (52.3{\%}) as compared with the dyspeptic control group (80{\%}). The initial H pylori status among subgroups I, II, and III was similar. There was a trend for the presence of H pylori in the stomach to decrease with increasing time elapsed after surgery (I to III: 68.8{\%}, 48.3{\%}, 36{\%}, respectively; p < 0.05). The maximum UBT sensitivity and specificity achieved were 82.2{\%} and 87.8{\%} in the gastrectomy group and 97.2{\%} and 96.3{\%} in the dyspeptic group, with cutoff points of 2.5 and 4.0, respectively. Conclusion: The prevalence of H pylori diminishes with time elapsed after gastrectomy. UBT for detection of H pylori is more effective in patients without prior gastrectomy than in patients who have undergone gastrectomy and is less effective than endoscopy for patients who have had a gastrectomy.",
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13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy. / Sheu, Bor Shyang; Lee, Shui Cheng; Lin, Pin Wen; Wang, Shan Tair; Chang, Yuh Chung; Yang, Hsiao Bai; Chuang, Chiao Hsiung; Lin, Xi Zhang.

於: Gastrointestinal Endoscopy, 卷 51, 編號 6, 01.01.2000, p. 670-675.

研究成果: Article

TY - JOUR

T1 - 13Carbon urea breath test is not as accurate as endoscopy to detect Helicobacter pylori after gastrectomy

AU - Sheu, Bor Shyang

AU - Lee, Shui Cheng

AU - Lin, Pin Wen

AU - Wang, Shan Tair

AU - Chang, Yuh Chung

AU - Yang, Hsiao Bai

AU - Chuang, Chiao Hsiung

AU - Lin, Xi Zhang

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Background: This study was conducted to determine (1) whether Helicobacter pylori infection decreases in conjunction with time elapsed after gastrectomy and (2) the diagnostic efficacy of 13C urea breath test (UBT) for H pylori in patients after gastrectomy. Methods: From January 1997 to June 1998, 86 patients who had undergone gastrectomy and 180 patients with dyspepsia without gastrectomy were enrolled. A UBT for the analysis of excess 13CO2/12CO2 ratio (ECR) was obtained for each patient. Each patient also underwent endoscopy to obtain gastric biopsies for histology and H pylori culture. The presence of H pylori by either histology or culture served as the standard to test the efficacy of UBT. The 86 patients with a prior gastrectomy were categorized into 3 subgroups (I, less than 1 year; II, 1 to 3 years; III, greater than 3 years), according to the interval between surgery and UBT. The initial H pylori status of these 86 patients was determined by histologic evaluation of the resected stomach. Results: M trial initiation, the postgastrectomy group had a lower H pylori infection rate (52.3%) as compared with the dyspeptic control group (80%). The initial H pylori status among subgroups I, II, and III was similar. There was a trend for the presence of H pylori in the stomach to decrease with increasing time elapsed after surgery (I to III: 68.8%, 48.3%, 36%, respectively; p < 0.05). The maximum UBT sensitivity and specificity achieved were 82.2% and 87.8% in the gastrectomy group and 97.2% and 96.3% in the dyspeptic group, with cutoff points of 2.5 and 4.0, respectively. Conclusion: The prevalence of H pylori diminishes with time elapsed after gastrectomy. UBT for detection of H pylori is more effective in patients without prior gastrectomy than in patients who have undergone gastrectomy and is less effective than endoscopy for patients who have had a gastrectomy.

AB - Background: This study was conducted to determine (1) whether Helicobacter pylori infection decreases in conjunction with time elapsed after gastrectomy and (2) the diagnostic efficacy of 13C urea breath test (UBT) for H pylori in patients after gastrectomy. Methods: From January 1997 to June 1998, 86 patients who had undergone gastrectomy and 180 patients with dyspepsia without gastrectomy were enrolled. A UBT for the analysis of excess 13CO2/12CO2 ratio (ECR) was obtained for each patient. Each patient also underwent endoscopy to obtain gastric biopsies for histology and H pylori culture. The presence of H pylori by either histology or culture served as the standard to test the efficacy of UBT. The 86 patients with a prior gastrectomy were categorized into 3 subgroups (I, less than 1 year; II, 1 to 3 years; III, greater than 3 years), according to the interval between surgery and UBT. The initial H pylori status of these 86 patients was determined by histologic evaluation of the resected stomach. Results: M trial initiation, the postgastrectomy group had a lower H pylori infection rate (52.3%) as compared with the dyspeptic control group (80%). The initial H pylori status among subgroups I, II, and III was similar. There was a trend for the presence of H pylori in the stomach to decrease with increasing time elapsed after surgery (I to III: 68.8%, 48.3%, 36%, respectively; p < 0.05). The maximum UBT sensitivity and specificity achieved were 82.2% and 87.8% in the gastrectomy group and 97.2% and 96.3% in the dyspeptic group, with cutoff points of 2.5 and 4.0, respectively. Conclusion: The prevalence of H pylori diminishes with time elapsed after gastrectomy. UBT for detection of H pylori is more effective in patients without prior gastrectomy than in patients who have undergone gastrectomy and is less effective than endoscopy for patients who have had a gastrectomy.

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U2 - 10.1067/mge.2000.105719

DO - 10.1067/mge.2000.105719

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