Suppression of natural killer cell activity in mouse spleen lymphocytes by several dopamine receptor antagonists

S. J. Won, Y. C. Chuang, W. T. Huang, H. S. Liu, M. T. Lin

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

The effects of dopaminergic receptor inhibitors such as thiothixine (D1/D2), fluphenazine (D1/D2), trifluoperazine (D1/D2), pimozide (D2), flupenthixol (D1/D2), (+/-)-SKF 83566 (D1), and spiperone (D2) on splenic natural killer (NK) cell cytotoxic activities were assessed in vitro using mouse spleen lymphocytes or enriched NK cells. Both the activities of the splenic NK cell cytotoxicity and the effector-target cell conjugation were suppressed by thiothixine, fluphenazine, and trifluoperazine at concentrations from 2.64 to 14.78 μM. In addition, the augmentation of the cytolytic activity of NK cells induced by interferon-α or interleukin-2 was antagonized by pretreatment with these neuroleptic compounds. However, neither the splenic NK cell cytotoxicity nor the effector-target cell conjugation were affected by treatment with other neuroleptic compounds such as pimozide, flupenthixol, (+/-)-SKF 83566, and spiperone. Thus, it appears that neuroleptic compounds such as thiothixine, fluphenazine, and trifluoperazine may act through the mechanisms other than a dopaminergic pathway to affect the NK cell-target cell interaction.

原文English
頁(從 - 到)343-348
頁數6
期刊Experientia
51
發行號4
DOIs
出版狀態Published - 1995 四月

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)

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