Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

Yu Peng Liu, Jih Jong Lee, Tsung Ching Lai, Chien Hsin Lee, Ya Wen Hsiao, Po Shen Chen, Wei Ting Liu, Chi Yuan Hong, Se Kwan Lin, Mark Yen Ping Kuo, Pei Jung Lu, Michael Hsiao

研究成果: Article

19 引文 斯高帕斯(Scopus)

摘要

Background Deguelin has both antiproliferation and antimetastasis activities. However, high-dose deguelin elicits many undesired side effects. The purpose of this study was to investigate whether the low-dose deguelin can prevent the metastasis of oral cancer. Methods The dose effects of deguelin on metastasis of oral cancer cells were analyzed by in vitro invasion assay and an orthotropic xenograft mouse model. The involvement of tumor necrosis factor alpha (TNF-α)-induced nuclear factor-kappa B (NF-κB) signaling was examined by Western blot and reporter assay. Results Low-dose deguelin, which has minimal cytotoxicity, significantly inhibited the invasion and migration of oral cancer cells. These inhibitory effects of low-dose deguelin were mediated by suppressing TNF-α-induced activation of IκB kinase leading to the inhibition of IκB phosphorylation, NF-κB transcriptional activity, and matrix metalloproteinase-2 (MMP2) expression. The low-dose deguelin treatment significantly inhibited tumor growth and invasion without systemic toxicity. Conclusion The low-dose deguelin suppressed the invasion and migration of oral cancer by downregulating TNF-α-induced NF-κB signaling.

原文English
頁(從 - 到)E524-E534
期刊Head and Neck
38
DOIs
出版狀態Published - 2016 四月 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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    Liu, Y. P., Lee, J. J., Lai, T. C., Lee, C. H., Hsiao, Y. W., Chen, P. S., Liu, W. T., Hong, C. Y., Lin, S. K., Ping Kuo, M. Y., Lu, P. J., & Hsiao, M. (2016). Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling. Head and Neck, 38, E524-E534. https://doi.org/10.1002/hed.24034