Surface characterization and platelet compatibility evaluation of binary mixed self-assembled monolayers containing novel sulfonic acid terminated alkanethiol

Ching Hsiung Shen, Jui-Che Lin

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

The interactions between the biological environment and artificial surface are greatly influenced by the surface characteristics of substrate. Self-assembled monolayer prepared by long-chain alkanethiol on gold has been considered as a good model surface to study the effects of surface characteristics upon biological responses. In this study, two different series of mixed SAMs prepared by lab-synthesized sulfonic acid terminated alkanethiol with hydrophobic -CH3 or hydrophilic -OH terminated one were characterized. It was noted that the surface hydrophilicity of -SO3H/-CH3 mixed SAMs was increased with the solution mole fraction of -SO3H terminated thiol. However, the surfaces were all hydrophilic on the -SO3H/-OH mixed SAMs. All of these mixed SAMs were " -SO3H poor" and negatively charged on surface. In vitro platelet adhesion study indicated that -SO3H/-OH mixed SAMs exhibited a better platelet compatibility than -SO3H/-CH3 mixed ones, suggesting a surface with fair hydrophilicity and least negative surface charges might be of potential as a candidate for developing a platelet/blood compatible artificial surface.

原文English
頁(從 - 到)156-163
頁數8
期刊Colloids and Surfaces B: Biointerfaces
79
發行號1
DOIs
出版狀態Published - 2010 八月 1

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 膠體和表面化學
  • 物理與理論化學
  • 表面和介面

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