Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease

Miao Hsi Hsieh, Pei Chi Chen, Han Yin Hsu, Jui Chang Liu, Yu Sheng Ho, Yuh Jyh Lin, Chin Wei Kuo, Wen Shuo Kuo, Hui Fang Kao, Shulhn Der Wang, Zhi Gang Liu, Lawrence Shih Hsin Wu, Jiu Yao Wang

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs) are frequently found under oxidative stress conditions and/or in patients with chronic obstructive pulmonary disease (COPD) who are also chronically exposed to cigarette smoke (CS). However, the roles and molecular mechanisms of SP-D and FMs in COPD have not yet been determined. In this study, increased levels of SP-D were found in the bronchoalveolar lavage fluid (BALF) and sera of ozone- and CS-exposed mice. Furthermore, SP-D-knockout mice showed increased lipid-laden FMs and airway inflammation caused by ozone and CS exposure, similar to that exhibited by our study cohort of chronic smokers and COPD patients. We also showed that an exogenous recombinant fragment of human SP-D (rfhSP-D) prevented the formation of oxidized low-density lipoprotein (oxLDL)-induced FMs in vitro and reversed the airway inflammation and emphysematous changes caused by oxidative stress and CS exposure in vivo. SP-D upregulated bone marrow-derived macrophage (BMDM) expression of genes involved in countering the oxidative stress and lipid metabolism perturbations induced by CS and oxLDL. Our study demonstrates the crucial roles of SP-D in the lipid homeostasis of dysfunctional alveolar macrophages caused by ozone and CS exposure in experimental mouse emphysema, which may provide a novel opportunity for the clinical application of SP-D in patients with COPD.

原文English
頁(從 - 到)38-50
頁數13
期刊Cellular and Molecular Immunology
20
發行號1
DOIs
出版狀態Published - 2023 1月

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 免疫學
  • 傳染性疾病

指紋

深入研究「Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease」主題。共同形成了獨特的指紋。

引用此