Swelling Controlled Release of Drug from Polymetric Delivery Devices: A Local Similarity Solution

Jenn Sen Lin, Chi Chuan Hwang, Jin Yuan Hsieh, Shio Chao Lee

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

This paper presents a numerically integrated solution of moving boundary problems involving mass diffusion in polymer-penetrant system with a swelling controlled release of drug. Dividing the diffusion process into a finite number of fixed boundary problems, we have assumed the local similarity assumption to valid during the short period. Unlike the existing parameter expansion methods, the present solution is expected to be valid over a large range of control parameter representing the difference between solvent concentration at interface and the equilibrium value within the polymer. At small times, our numerical result shows that a larger values of the control parameter leads to a shorter interval for zero order drug release providing a higher release rate.

原文English
頁(從 - 到)1991-1998
頁數8
期刊Journal of the Physical Society of Japan
69
發行號7
DOIs
出版狀態Published - 2000 7月

All Science Journal Classification (ASJC) codes

  • 物理與天文學 (全部)

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