Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice

Hans I.Chen Harn, Sheng Pei Wang, Yung Chih Lai, Ben Van Handel, Ya Chen Liang, Stephanie Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, Stefan Kaemmer, Ming Jer Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting Xin Jiang, Cheng Ming Chuong

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Tissue regeneration is a process that recapitulates and restores organ structure and function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice (Mus), the regeneration is limited to the center of the wound unlike those observed in African spiny (Acomys) mice. Tissue mechanics have been implicated as an integral part of tissue morphogenesis. Here, we use the WIHN model to investigate the mechanical and molecular responses of laboratory and African spiny mice, and report these models demonstrate opposing trends in spatiotemporal morphogenetic field formation with association to wound stiffness landscapes. Transcriptome analysis and K14-Cre-Twist1 transgenic mice show the Twist1 pathway acts as a mediator for both epidermal-dermal interactions and a competence factor for periodic patterning, differing from those used in development. We propose a Turing model based on tissue stiffness that supports a two-scale tissue mechanics process: (1) establishing a morphogenetic field within the wound bed (mm scale) and (2) symmetry breaking of the epidermis and forming periodically arranged hair primordia within the morphogenetic field (μm scale). Thus, we delineate distinct chemo-mechanical events in building a Turing morphogenesis-competent field during WIHN of laboratory and African spiny mice and identify its evo-devo advantages with perspectives for regenerative medicine.

原文English
文章編號2595
期刊Nature communications
12
發行號1
DOIs
出版狀態Published - 2021 12月 1

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 物理與天文學 (全部)

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