Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

Jih Ru Hwu, Shwu Chen Tsay, Kao Shu Chuang, Mohit Kapoor, Jia Yu Lin, Chen Sheng Yeh, Wu Chou Su, Ping Ching Wu, Tsung Lin Tsai, Pei Wen Wang, Dar Bin Shieh

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

原文English
頁(從 - 到)1926-1930
頁數5
期刊Chemistry - A European Journal
22
發行號6
DOIs
出版狀態Published - 2016 二月 5

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

指紋 深入研究「Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs」主題。共同形成了獨特的指紋。

引用此