Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

Jih Ru Hwu, Shwu Chen Tsay, Kao Shu Chuang, Mohit Kapoor, Jia Yu Lin, Chen Sheng Yeh, Wu Chou Su, Ping Ching Wu, Tsung Lin Tsai, Pei Wen Wang, Dar Bin Shieh

研究成果: Article

3 引文 (Scopus)

摘要

Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

原文English
頁(從 - 到)1926-1930
頁數5
期刊Chemistry - A European Journal
22
發行號6
DOIs
出版狀態Published - 2016 二月 5

指紋

Sulindac
Platinum
Cells
Nanoparticles
Pharmaceutical Preparations
Acids
Dimethyl Sulfoxide
Thymidine
Milk

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

引用此文

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title = "Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs",
abstract = "Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.",
author = "Hwu, {Jih Ru} and Tsay, {Shwu Chen} and Chuang, {Kao Shu} and Mohit Kapoor and Lin, {Jia Yu} and Yeh, {Chen Sheng} and Su, {Wu Chou} and Wu, {Ping Ching} and Tsai, {Tsung Lin} and Wang, {Pei Wen} and Shieh, {Dar Bin}",
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Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs. / Hwu, Jih Ru; Tsay, Shwu Chen; Chuang, Kao Shu; Kapoor, Mohit; Lin, Jia Yu; Yeh, Chen Sheng; Su, Wu Chou; Wu, Ping Ching; Tsai, Tsung Lin; Wang, Pei Wen; Shieh, Dar Bin.

於: Chemistry - A European Journal, 卷 22, 編號 6, 05.02.2016, p. 1926-1930.

研究成果: Article

TY - JOUR

T1 - Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

AU - Hwu, Jih Ru

AU - Tsay, Shwu Chen

AU - Chuang, Kao Shu

AU - Kapoor, Mohit

AU - Lin, Jia Yu

AU - Yeh, Chen Sheng

AU - Su, Wu Chou

AU - Wu, Ping Ching

AU - Tsai, Tsung Lin

AU - Wang, Pei Wen

AU - Shieh, Dar Bin

PY - 2016/2/5

Y1 - 2016/2/5

N2 - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

AB - Platinum(II)-sulindac complexes [{η2-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η2-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species. Potency! Two new types of PtII-sulindac complexes were synthesized that exhibited remarkable IC50 values against human cancer cells OECM1 (see scheme). These compounds could be applied for targeted cancer chemotherapeutics.

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