Synthesis and antiplatelet activity of 3,5,6,7,8,2',3' and 4'- monosubstituted 2-phenyl-4-quinolones

Ming Chieh Hsieh, Li Jiau Huang, Kuo Hsiung Lee, Tian Shung Wu, Sheng Chih Chen, Che Ming Teng, Sheng Chu Kuo

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

In a continuation of our search for novel antiplatelet agents, a series of 3,5,6,7,8,2',3' and 4'-monosubstituted derivatives of 2-phenyl-4-quinolone were synthesized and their inhibitory effects against arachidonic acid (AA)- induced platelet aggregation were evaluated. Although no regular or definite structure-activity relationships were observed, some compounds exhibited significant inhibitory activity. Among them, 5-ethyl-2-phenyl-4-quinolone (19) displayed the highest potency, outperformed indomethacin, and was chosen as a lead compound for structural modification.

原文English
頁(從 - 到)67-80
頁數14
期刊Chinese Pharmaceutical Journal
50
發行號2
出版狀態Published - 1998 四月

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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