Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Jang Yang Chang, Mei Jung Lai, Yi Ting Chang, Hsueh Yun Lee, Yun Ching Cheng, Ching Chuan Kuo, Min Chieh Su, Chi Yen Chang, Jing Ping Liou

研究成果: Article

19 引文 斯高帕斯(Scopus)

摘要

A series of 7-arylindoline-1-benzenesulfonamides were prepared and evaluated for anticancer activity. 7-(4′-Cyanophenyl)indoline-1- benzenesulfonamide 15 exhibited substantial antiproliferative activity with IC50 values ranging from 17-32 nM against a variety of human cancer cell lines, including MDR resistant line. Compound 15 (IC50 = 1.5 μM) also showed more potent inhibition of tubulin polymerization than 4a (combretastatin A-4, IC50 = 2.0 μM) and displayed strong binding to the colchicine binding site of the tubulin.

原文English
頁(從 - 到)152-155
頁數4
期刊MedChemComm
1
發行號2
DOIs
出版狀態Published - 2010 八月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

引用此

Chang, J. Y., Lai, M. J., Chang, Y. T., Lee, H. Y., Cheng, Y. C., Kuo, C. C., Su, M. C., Chang, C. Y., & Liou, J. P. (2010). Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents. MedChemComm, 1(2), 152-155. https://doi.org/10.1039/c0md00052c