Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Mopur Vijaya Bhaskar Reddy, Hsin Yi Hung, Ping Chung Kuo, Guan Jhong Huang, Yu Yi Chan, Shiow Chyn Huang, Shwu Jen Wu, Susan L. Morris-Natschke, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

Twenty-one chalcones were prepared via aldol condensation and subsequent reduction of these compound led to the corresponding dihydrochalcone and 1,3-diphenylpropane derivatives. The synthetic products were examined for their effects on NO inhibition in LPS-activated mouse peritoneal macrophages. Among the tested compounds, a 1,3-diarylpropane analog, 2-(3-(3,4-dimethoxyphenyl)propyl)-5-methoxyphenol (3p), displayed the most significant inhibitory effects against NO production. To investigate the mechanism of action, the effects of 3p on iNOS and COX-2 protein expression were studied by immunoblot. The results concluded that 3p is capable of inhibiting iNOS expression in LPS-induced RAW264.7 cells via attenuation of NF-κB signaling by ERK, p38, and JNK.

原文English
頁(從 - 到)1547-1550
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
27
發行號7
DOIs
出版狀態Published - 2017

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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