TY - JOUR
T1 - Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity
AU - Reddy, Mopur Vijaya Bhaskar
AU - Kuo, Ping Chung
AU - Hung, Hsin Yi
AU - Tsai, Wei Jern
AU - Wu, Tian Shung
N1 - Funding Information:
thankful for the support in part by Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH100-TD-B-111-004).
Funding Information:
This study was sponsored by the grant from Ministry of Science and Technology, Taiwan, ROC and grant (No.OUA 95-3-2-021) from National Cheng Kung University, Tainan, Taiwan, ROC awarded to T. S. Wu. Authors were also thankful for the support in part by Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH100-TD-B-111-004).
Funding Information:
This study was sponsored by the grant from Ministry of Science and Technology, Taiwan, ROC and grant (No.OUA 95-3-2-021) from National Cheng Kung University, Tainan, Taiwan, ROC awarded to T. S. Wu. Authors were also
PY - 2016
Y1 - 2016
N2 - A series of 3-arylidenechroman-4-one derivatives (1-16) have been synthesized in good yields from chroman-4-one and different substituted aldehydes by the Claisen-Schmidt condensation. All the synthesized compounds were characterized by using spectroscopic analyses including IR, 1H NMR, 13C NMR, EIMS and HREIMS. The synthesized compounds were screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by adenosine diphosphate (20 μM) and collagen (10 μg/mL). Compounds 1 (81.3%), 11 (88.7%), and 13 (85.0 %) were showed potent inhibitory effects on ADP-induced aggregation activity, in which their structures possessed 2-thiophene, 3,5-dimethoxybenzene and 2,3-dimethoxybenzene moieties in the B-ring, respectively.
AB - A series of 3-arylidenechroman-4-one derivatives (1-16) have been synthesized in good yields from chroman-4-one and different substituted aldehydes by the Claisen-Schmidt condensation. All the synthesized compounds were characterized by using spectroscopic analyses including IR, 1H NMR, 13C NMR, EIMS and HREIMS. The synthesized compounds were screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by adenosine diphosphate (20 μM) and collagen (10 μg/mL). Compounds 1 (81.3%), 11 (88.7%), and 13 (85.0 %) were showed potent inhibitory effects on ADP-induced aggregation activity, in which their structures possessed 2-thiophene, 3,5-dimethoxybenzene and 2,3-dimethoxybenzene moieties in the B-ring, respectively.
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M3 - Article
AN - SCOPUS:85018204322
SN - 0975-5071
VL - 8
SP - 14
EP - 20
JO - Der Pharmacia Lettre
JF - Der Pharmacia Lettre
IS - 20
ER -