TY - JOUR
T1 - Synthesis and characterization of a poly(GMA)-graftpoly(Z-L-lysine) graft copolymer with a rod-like structure
AU - Tu, You Liang
AU - Wang, Cheng Chien
AU - Chen, Chuh Yung
PY - 2009/9/15
Y1 - 2009/9/15
N2 - This study applied the macromonomers and glycidyl methacrylate (GMA) to synthesize a series of the graft copolymers, poly(GMA)-graft-poly(Z-L-lysine), and investigated the conformation of the graft copolymer. The graft copolymers were synthesized with different GMA monomer ratios (28 to 89%) and different degrees of polymerization (DP) (8 to 15) of the poly(Z-L-lysine) side chain to analyze secondary structure relationships. Atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and both wide angle and small angle X-ray scattering spectroscopy (WAXS, SAXS) were used to investigate the relationship between the microstructure and conformation of the graft copolymers and the different monomer ratios and side chain DP. In AFM images, n8-G89 (the graft copolymer containing 89% GMA units and the macromonomer DP is 8) showed tiny and uniform rod-like structures, and nl4-G43 (the graft copolymer containing 43% GMA units and the macromonomer DP is 14) showed uniform rod-like structures. FTIR spectra of the graft copolymers showed that the variations of α-helix and beta;-sheet secondary structures in the graft copolymers relate to the monomer ratios of the graft copolymers. However, the X-ray scattering patterns indicated that the graft copolymer conformations were mainly dependent on the poly(Z-L-lysine) side chain length, and these results were completely in accordance with the AFM images.
AB - This study applied the macromonomers and glycidyl methacrylate (GMA) to synthesize a series of the graft copolymers, poly(GMA)-graft-poly(Z-L-lysine), and investigated the conformation of the graft copolymer. The graft copolymers were synthesized with different GMA monomer ratios (28 to 89%) and different degrees of polymerization (DP) (8 to 15) of the poly(Z-L-lysine) side chain to analyze secondary structure relationships. Atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and both wide angle and small angle X-ray scattering spectroscopy (WAXS, SAXS) were used to investigate the relationship between the microstructure and conformation of the graft copolymers and the different monomer ratios and side chain DP. In AFM images, n8-G89 (the graft copolymer containing 89% GMA units and the macromonomer DP is 8) showed tiny and uniform rod-like structures, and nl4-G43 (the graft copolymer containing 43% GMA units and the macromonomer DP is 14) showed uniform rod-like structures. FTIR spectra of the graft copolymers showed that the variations of α-helix and beta;-sheet secondary structures in the graft copolymers relate to the monomer ratios of the graft copolymers. However, the X-ray scattering patterns indicated that the graft copolymer conformations were mainly dependent on the poly(Z-L-lysine) side chain length, and these results were completely in accordance with the AFM images.
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U2 - 10.1002/pola.23516
DO - 10.1002/pola.23516
M3 - Article
AN - SCOPUS:69549138590
VL - 47
SP - 4655
EP - 4669
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
SN - 0887-624X
IS - 18
ER -