TY - JOUR
T1 - Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids
AU - Hsieh, Hsing Pang
AU - Muller, James G.
AU - Burrows, Cynthia J.
PY - 1995/6
Y1 - 1995/6
N2 - Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.
AB - Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.
UR - https://www.scopus.com/pages/publications/0029061568
UR - https://www.scopus.com/pages/publications/0029061568#tab=citedBy
U2 - 10.1016/0968-0896(95)00060-T
DO - 10.1016/0968-0896(95)00060-T
M3 - Article
C2 - 7582959
AN - SCOPUS:0029061568
SN - 0968-0896
VL - 3
SP - 823
EP - 838
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 6
ER -