Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

Hsing Pang Hsieh; James G. Muller; Cynthia J. Burrows

doi:10.1016/0968-0896(95)00060-T

Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

Hsing Pang Hsieh
, James G. Muller
, Cynthia J. Burrows

奈米醫學研究中心

研究成果: Article › 同行評審

30 引文斯高帕斯（Scopus）

摘要

Seven new amino- and guanidino-substituted steroids have been synthesized from bile acid precursors, either deoxycholic acid or lithocholic acid. Their DNA binding properties have been examined using an ethidium displacement assay, through studies of hyperchromicity and thermal denaturation, and by circular dichroism. Comparison is made to simple aliphatic polyamines such as putrescine, 1,12-diaminododecane, spermidine, and spermine.

原文	English
頁（從 - 到）	823-838
頁數	16
期刊	Bioorganic and Medicinal Chemistry
卷	3
發行號	6
DOIs	https://doi.org/10.1016/0968-0896(95)00060-T
出版狀態	Published - 1995 6月

All Science Journal Classification (ASJC) codes

生物化學
分子醫學
分子生物學
藥學科學
藥物發現
臨床生物化學
有機化學

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10.1016/0968-0896(95)00060-T

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ER -

Synthesis and DNA binding properties of C3-, C12-, and C24- substituted amino-steroids derived from bile acids

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