Synthesis and evaluation of the cytotoxicities of neoflavenes

Sie Rong Li, Hsing Ming Chen, Po Yuan Chen, Jui Chi Tsai, Liang Yeu Chen, Eng Chi Wang, Yi Ting Huang, Yun Chen Wei, Pei Jung Lu

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed. In particular, 6f which exhibited an IC50 value of 6.5 ± 2.0 and 5.1 ± 1.1 μM against gastric carcinoma and lung carcinoma cells in vitro was found, respectively. Meanwhile, the structure and activity relationship of our synthesized neoflavenes is further discussed briefly.

原文English
頁(從 - 到)923-932
頁數10
期刊Journal of the Chinese Chemical Society
55
發行號4
DOIs
出版狀態Published - 2008 1月 1

All Science Journal Classification (ASJC) codes

  • 化學 (全部)

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