TY - JOUR
T1 - Synthesis of 1-(2-Carboxyethylbenzyl)-2-benzenesulfonamidobicyclo[2.2.1]heptane
T2 - A Novel Potent Thromboxane Antagonist
AU - Kan, Wai Ming
AU - Chern, Ching Yuh
AU - Su, Sheng Fang
PY - 1998
Y1 - 1998
N2 - A potent thromboxane antagonist, 1-[2-(2-carboxyethyl)benzyl)]-2-benzenesulfonamidobicyclo-[2.2.1]heptane was synthesized from norcamphor in 8 steps. It was shown to be a very potent thromboxane antagonist by inhibition of platelet aggregation induced by U46,619 at nanomolar concentration. The key intermediate 3-[2-bromomethylphenyl]propyl tetrahydropyran ether may be useful for the synthesis of other interphenylene containing prostaglandin analogs.
AB - A potent thromboxane antagonist, 1-[2-(2-carboxyethyl)benzyl)]-2-benzenesulfonamidobicyclo-[2.2.1]heptane was synthesized from norcamphor in 8 steps. It was shown to be a very potent thromboxane antagonist by inhibition of platelet aggregation induced by U46,619 at nanomolar concentration. The key intermediate 3-[2-bromomethylphenyl]propyl tetrahydropyran ether may be useful for the synthesis of other interphenylene containing prostaglandin analogs.
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U2 - 10.1002/jccs.199800107
DO - 10.1002/jccs.199800107
M3 - Article
AN - SCOPUS:0345759202
SN - 0009-4536
VL - 45
SP - 711
EP - 712
JO - Journal of the Chinese Chemical Society
JF - Journal of the Chinese Chemical Society
IS - 6
ER -