Synthesis of analogues of gingerol and shogaol, the active pungent principles from the rhizomes of Zingiber officinale and evaluation of their anti-platelet aggregation effects

Hung Cheng Shih, Ching Yuh Chern, Ping Chung Kuo, You Cheng Wu, Yu Yi Chan, Yu Ren Liao, Che Ming Teng, Tian Shung Wu

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, [6]-paradol (5b) exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.

原文English
頁(從 - 到)3926-3951
頁數26
期刊International journal of molecular sciences
15
發行號3
DOIs
出版狀態Published - 2014 三月 4

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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