Synthesis of ion-pair amphiphiles and calorimetric study on the gel to liquid-crystalline phase transition behavior of their bilayers

Wei Han Lee, Yi Li Tang, Tzu Chin Chiu, Yu Min Yang

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

In this work, nine homologous ion-pair amphiphiles (IPAs) were successfully prepared by the precipitation or ion-exchange methods. This demonstrated the feasibility of designing and synthesizing lipid-like amphiphiles from cheap and abundant single-chained cationic and anionic amphiphiles. The thermotropic transition behavior from gel phase (Lβ) through rippled phase (Pβ′) to liquid-crystalline phase (Lα) of these IPA bilayers in water was thereafter systematically studied by using differential scanning calorimetry. A database of pretransition temperature, main transition temperature, and the corresponding transition enthalpy/entropy of the nine IPA bilayers was documented. Different phase transition behavior is exhibited by IPA bilayers with different hydrocarbon chain lengths and symmetry. The main phase transition temperature (Tm) is consistently higher for IPAs with higher total number of carbon atoms in the hydrocarbon chains. For IPAs with the same total number of carbon atoms in the hydrocarbon chains, the Tm is higher for the symmetric one than that of the asymmetric one. Furthermore, much higher Tm was exhibited by IPA as compared with that of phosphatidylcholine based on the same total number of carbon atoms in the hydrocarbon chains. These fundamental properties of IPAs definitely help understand membrane characteristics of catanionic vesicles, which were fabricated from IPAs, for potential applications in drug delivery and gene therapy.

原文English
頁(從 - 到)1119-1125
頁數7
期刊Journal of Chemical and Engineering Data
60
發行號4
DOIs
出版狀態Published - 2015 四月 9

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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