Synthesis of polynucleotide modified gold nanoparticles as a high potent anti-Cancer drug carrier

Ching Ming Wu, Ping-Ching Wu, Yun Han Wang, Tsung Ju Li, Li Xing Yang, Ya Na Wu, Hsi Yuan Yang, Dar-Bin Shieh

研究成果: Article

5 引文 (Scopus)

摘要

Gold nanoparticles have been developed for the photoacoustic imaging, delivery of genes and laser induced photothermal therapy. In this study, we have developed oligonucleotide conjugated gold nanoparticles as the carrier for simultaneous DNA and anti-cancer nucleoside delivery. The polynucleotidenanoparticle complex presented higher capacity in carrying 5-FU anti-cancer compounds than the original gold particles. The hydrodynamic size of the gold nanoparticles increased from 25 to 35 nm with an increase in the negative surface charge from -9.58 to 21.66 mV after polynucleotide conjugation and drug loading. A positive association between environmental pH and drug release was observed in PBS, which implied their potential use in the controlled localized drug release in the lower GI tract. The MTTassay revealed dose dependent cytotoxicity to colon cancer cell line than free compounds. These results suggest the potential use of this new polynucleotide-gold nanoparticles complex as the environmental controlled anti-cancer nanocapsule, especially suitable for per oral colon cancer chemotherapy.

原文English
頁(從 - 到)703-708
頁數6
期刊Journal of the Chinese Chemical Society
56
發行號4
DOIs
出版狀態Published - 2009 一月 1

指紋

Polynucleotides
Drug Carriers
Gold
Nanoparticles
Pharmaceutical Preparations
Nanocapsules
Chemotherapy
Photoacoustic effect
Cytotoxicity
Surface charge
Nucleosides
Oligonucleotides
Fluorouracil
Hydrodynamics
Genes
Cells
Association reactions
Imaging techniques
Lasers
DNA

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

引用此文

Wu, Ching Ming ; Wu, Ping-Ching ; Wang, Yun Han ; Li, Tsung Ju ; Yang, Li Xing ; Wu, Ya Na ; Yang, Hsi Yuan ; Shieh, Dar-Bin. / Synthesis of polynucleotide modified gold nanoparticles as a high potent anti-Cancer drug carrier. 於: Journal of the Chinese Chemical Society. 2009 ; 卷 56, 編號 4. 頁 703-708.
@article{5fb438cbbe514cabb21b1ecd351282b0,
title = "Synthesis of polynucleotide modified gold nanoparticles as a high potent anti-Cancer drug carrier",
abstract = "Gold nanoparticles have been developed for the photoacoustic imaging, delivery of genes and laser induced photothermal therapy. In this study, we have developed oligonucleotide conjugated gold nanoparticles as the carrier for simultaneous DNA and anti-cancer nucleoside delivery. The polynucleotidenanoparticle complex presented higher capacity in carrying 5-FU anti-cancer compounds than the original gold particles. The hydrodynamic size of the gold nanoparticles increased from 25 to 35 nm with an increase in the negative surface charge from -9.58 to 21.66 mV after polynucleotide conjugation and drug loading. A positive association between environmental pH and drug release was observed in PBS, which implied their potential use in the controlled localized drug release in the lower GI tract. The MTTassay revealed dose dependent cytotoxicity to colon cancer cell line than free compounds. These results suggest the potential use of this new polynucleotide-gold nanoparticles complex as the environmental controlled anti-cancer nanocapsule, especially suitable for per oral colon cancer chemotherapy.",
author = "Wu, {Ching Ming} and Ping-Ching Wu and Wang, {Yun Han} and Li, {Tsung Ju} and Yang, {Li Xing} and Wu, {Ya Na} and Yang, {Hsi Yuan} and Dar-Bin Shieh",
year = "2009",
month = "1",
day = "1",
doi = "10.1002/jccs.200900105",
language = "English",
volume = "56",
pages = "703--708",
journal = "Journal of the Chinese Chemical Society",
issn = "0009-4536",
publisher = "Chinese Chemical Society",
number = "4",

}

Synthesis of polynucleotide modified gold nanoparticles as a high potent anti-Cancer drug carrier. / Wu, Ching Ming; Wu, Ping-Ching; Wang, Yun Han; Li, Tsung Ju; Yang, Li Xing; Wu, Ya Na; Yang, Hsi Yuan; Shieh, Dar-Bin.

於: Journal of the Chinese Chemical Society, 卷 56, 編號 4, 01.01.2009, p. 703-708.

研究成果: Article

TY - JOUR

T1 - Synthesis of polynucleotide modified gold nanoparticles as a high potent anti-Cancer drug carrier

AU - Wu, Ching Ming

AU - Wu, Ping-Ching

AU - Wang, Yun Han

AU - Li, Tsung Ju

AU - Yang, Li Xing

AU - Wu, Ya Na

AU - Yang, Hsi Yuan

AU - Shieh, Dar-Bin

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Gold nanoparticles have been developed for the photoacoustic imaging, delivery of genes and laser induced photothermal therapy. In this study, we have developed oligonucleotide conjugated gold nanoparticles as the carrier for simultaneous DNA and anti-cancer nucleoside delivery. The polynucleotidenanoparticle complex presented higher capacity in carrying 5-FU anti-cancer compounds than the original gold particles. The hydrodynamic size of the gold nanoparticles increased from 25 to 35 nm with an increase in the negative surface charge from -9.58 to 21.66 mV after polynucleotide conjugation and drug loading. A positive association between environmental pH and drug release was observed in PBS, which implied their potential use in the controlled localized drug release in the lower GI tract. The MTTassay revealed dose dependent cytotoxicity to colon cancer cell line than free compounds. These results suggest the potential use of this new polynucleotide-gold nanoparticles complex as the environmental controlled anti-cancer nanocapsule, especially suitable for per oral colon cancer chemotherapy.

AB - Gold nanoparticles have been developed for the photoacoustic imaging, delivery of genes and laser induced photothermal therapy. In this study, we have developed oligonucleotide conjugated gold nanoparticles as the carrier for simultaneous DNA and anti-cancer nucleoside delivery. The polynucleotidenanoparticle complex presented higher capacity in carrying 5-FU anti-cancer compounds than the original gold particles. The hydrodynamic size of the gold nanoparticles increased from 25 to 35 nm with an increase in the negative surface charge from -9.58 to 21.66 mV after polynucleotide conjugation and drug loading. A positive association between environmental pH and drug release was observed in PBS, which implied their potential use in the controlled localized drug release in the lower GI tract. The MTTassay revealed dose dependent cytotoxicity to colon cancer cell line than free compounds. These results suggest the potential use of this new polynucleotide-gold nanoparticles complex as the environmental controlled anti-cancer nanocapsule, especially suitable for per oral colon cancer chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=77952534582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952534582&partnerID=8YFLogxK

U2 - 10.1002/jccs.200900105

DO - 10.1002/jccs.200900105

M3 - Article

AN - SCOPUS:77952534582

VL - 56

SP - 703

EP - 708

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

SN - 0009-4536

IS - 4

ER -