Synthesis of Quinolinium Salts from N-Substituted Anilines, Aldehydes, Alkynes, and Acids: Theoretical Understanding of the Mechanism and Regioselectivity

Lin Chieh Cheng, Wei Chen Chen, Rajagopal Santhoshkumar, Tzu Hsuan Chao, Mu Jeng Cheng, Chien Hong Cheng

研究成果: Article

摘要

Secondary anilines were first utilized in the four-component coupling of aniline, aldehyde, alkyne, and acid to synthesize a variety of N-substituted quinolinium salts. This method was carried out under mild reaction conditions and exhibited excellent chemo- and regioselectivities. DFT calculation was performed to analyze the cyclization step, where the interaction/distortion model provided better insight into the singular selectivity of terminal/internal alkynes in reaction.

原文English
頁(從 - 到)2116-2129
頁數14
期刊European Journal of Organic Chemistry
2020
發行號14
DOIs
出版狀態Published - 2020 四月 16

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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