Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation

Srinivasan Periasamy, Chia Hui Lin, Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R. Desai, Ming Yie Liu

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Ulcerative colitis (UC) is the leading chronic gastrointestinal disorder, if untreated can cause colon cancer. We characterized tamarind xyloglucan (TXG) as an edible nano-fiber and investigated its role in UC mice. TXG was an efficient free radical quencher and antioxidant in nature. TXG increased the cell viability in DSS-induced cytotoxicity of intestinal epithelial cells (IEC-6) and quenched intracellular reactive oxygen species in IEC-6 cells. Experimental colitis was induced in C57BL/6 mice by administering DSS 3% (w/v) in drinking water; TXG 100 and 300 mg/kg/day were given orally for 7 days simultaneously. TXG protected the colon by attenuating inflammatory cell infiltration, submucosal edema and crypt abscesses. TXG decreased oxidative stress by decreasing MDA, superoxide anion count, iNOS, NOX, COX-2 and p47 expression. Additionally, TXG decreased inflammation by decreasing TNF-α and increasing IL-10. Altogether, TXG is a novel antioxidant and plays an important role in attenuating DSS-induced UC in mice.

原文English
頁(從 - 到)327-338
頁數12
期刊Journal of Functional Foods
42
DOIs
出版狀態Published - 2018 三月 1

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 醫藥(雜項)
  • 營養與營養學

指紋

深入研究「Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation」主題。共同形成了獨特的指紋。

引用此