TY - GEN
T1 - Targeted drug-loading microbubbles with focused ultrasound induced blood-brain barrier disruption for glioma treatment
AU - Ting, Chien Yu
AU - Fan, Ching Hsiang
AU - Liu, Hao Li
AU - Yen, Tzu Chen
AU - Wei, Kuo Chen
AU - Yeh, Chih Kuang
PY - 2012
Y1 - 2012
N2 - Focused ultraousnd (FUS) with the presence of microbubbles (MBs) has been demonstrated its capability of temporally and locally open the blood-brain barrier (BBB) that can be utilized to enhance chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. However, the current administered chemotherapeutic agents that provide tumor-killing effect also induce systemic toxicity that significantly limits the dosage. Our previous results have already demonstrated the success of concurrently applying drug (BCNU)-loaded MBs with FUS exposures to open the BBB, which provided benefits in local drug delivery and reduced systemic toxicity. To further enhance the drug targeting and releasing capability of the drug-loaded MBs, we demonstrated here a novel VEGF-targeting, drug-loaded microbubble design for the use of FUS-BBB opening and brain drug delivery. This study may provide useful implications toward future MB design which aims to perform the targeted brain tumor therapy or extend the application of microbubbles on theragnostic purpose.
AB - Focused ultraousnd (FUS) with the presence of microbubbles (MBs) has been demonstrated its capability of temporally and locally open the blood-brain barrier (BBB) that can be utilized to enhance chemotherapeutic drug delivery into the brain parenchyma for glioma treatment. However, the current administered chemotherapeutic agents that provide tumor-killing effect also induce systemic toxicity that significantly limits the dosage. Our previous results have already demonstrated the success of concurrently applying drug (BCNU)-loaded MBs with FUS exposures to open the BBB, which provided benefits in local drug delivery and reduced systemic toxicity. To further enhance the drug targeting and releasing capability of the drug-loaded MBs, we demonstrated here a novel VEGF-targeting, drug-loaded microbubble design for the use of FUS-BBB opening and brain drug delivery. This study may provide useful implications toward future MB design which aims to perform the targeted brain tumor therapy or extend the application of microbubbles on theragnostic purpose.
UR - http://www.scopus.com/inward/record.url?scp=84882430371&partnerID=8YFLogxK
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U2 - 10.1109/ULTSYM.2012.0467
DO - 10.1109/ULTSYM.2012.0467
M3 - Conference contribution
AN - SCOPUS:84882430371
SN - 9781467345613
T3 - IEEE International Ultrasonics Symposium, IUS
SP - 1862
EP - 1865
BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012
T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012
Y2 - 7 October 2012 through 10 October 2012
ER -