Targeted lipidomics: Discovery of new fatty acyl amides

Bo Tan, Heather B. Bradshaw, Neta Rimmerman, Harini Srinivasan, Y. William Yu, Jocelyn F. Krey, M. Francesca Monn, J. Shih Chieh Chen, Sherry Shu Jung Hu, Sarah R. Pickens, J. Michael Walker

研究成果: Article同行評審

54 引文 斯高帕斯(Scopus)

摘要

The discovery of endogenous fatty acyl amides such as N-arachidonoyl ethanolamide (anandamide), N-oleoyl ethanolamide (OEA), and N-arachidonoyl dopamine (NADA) as important signaling molecules in the central and peripheral nervous system has led us to pursue other unidentified signaling molecules. Until recently, technical challenges, particularly those associated with lipid purification and chemical analysis, have hindered the identification of low abundance signaling lipids. Improvements in chromatography and mass spectrometry (MS) such as miniaturization of high-performance liquid chromatography components, hybridization of multistage mass spectrometers and time-of-flight technology, the development of electrospray ionization (ESI) and of information-dependent acquisition, now permit rapid identification of novel, low abundance, signaling lipids.

原文English
文章編號54
頁(從 - 到)E461-E465
期刊AAPS Journal
8
發行號3
DOIs
出版狀態Published - 2006 7月 14

All Science Journal Classification (ASJC) codes

  • 藥學科學

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