Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu; Yu Sern Lin; Thainashmuthu Josephrajan; Ming Hua Hsu; Fong Yu Cheng; Chen Sheng Yeh; Wu Chou Su; Dar Bin Shieh

doi:10.1021/ja804947u

Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

Jih Ru Hwu, Yu Sern Lin, Thainashmuthu Josephrajan, Ming Hua Hsu, Fong Yu Cheng, Chen Sheng Yeh, Wu Chou Su, Dar Bin Shieh

研究成果: Article › 同行評審

172 引文斯高帕斯（Scopus）

摘要

The Fe₃O₄ nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

原文	English
頁（從 - 到）	66-68
頁數	3
期刊	Journal of the American Chemical Society
卷	131
發行號	1
DOIs	https://doi.org/10.1021/ja804947u
出版狀態	Published - 2009 1月 14

All Science Journal Classification (ASJC) codes

催化
一般化學
生物化學
膠體和表面化學

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10.1021/ja804947u

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AU - Josephrajan, Thainashmuthu

AU - Hsu, Ming Hua

AU - Cheng, Fong Yu

AU - Yeh, Chen Sheng

AU - Su, Wu Chou

AU - Shieh, Dar Bin

PY - 2009/1/14

Y1 - 2009/1/14

N2 - The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

AB - The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

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Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles

摘要

All Science Journal Classification (ASJC) codes

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