Targeting promyelocytic leukemia protein: A means to regulating PML nuclear bodies

Erin L. Reineke, Hung Ying Kao

研究成果: Review article

32 引文 (Scopus)

摘要

The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities often rely on the localization of PML to unique subnuclear structures known as PML nuclear bodies (NBs). More than 50 cellular proteins are known to traffic in and out of PML NBs, either transiently or constitutively. In order to understand the dynamics of these NBs, it is important to delineate the regulation of PML itself. PML is subject to extensive regulation at transcriptional, post-transcriptional, and post-translational levels. Many of these modes of regulation depend on the cellular context and the presence of extracellular signals. This review focuses on the current knowledge of regulation of PML under normal cellular conditions as well as the role for regulation of PML in viral infection and cancer.

原文English
頁(從 - 到)366-376
頁數11
期刊International Journal of Biological Sciences
5
發行號4
DOIs
出版狀態Published - 2009 一月 1

指紋

nuclear proteins
Staphylococcal Protein A
leukemia
targeting
protein
proteins
Virus Diseases
leukaemia
Promyelocytic Leukemia Protein
viral proteins
apoptosis
traffic
infection
DNA damage
DNA Damage
cell cycle
Cell Cycle
regulation
cancer
Apoptosis

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

引用此文

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Targeting promyelocytic leukemia protein : A means to regulating PML nuclear bodies. / Reineke, Erin L.; Kao, Hung Ying.

於: International Journal of Biological Sciences, 卷 5, 編號 4, 01.01.2009, p. 366-376.

研究成果: Review article

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