Targeting promyelocytic leukemia protein: A means to regulating PML nuclear bodies

Erin L. Reineke, Hung Ying Kao

研究成果: Review article同行評審

33 引文 斯高帕斯(Scopus)

摘要

The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities often rely on the localization of PML to unique subnuclear structures known as PML nuclear bodies (NBs). More than 50 cellular proteins are known to traffic in and out of PML NBs, either transiently or constitutively. In order to understand the dynamics of these NBs, it is important to delineate the regulation of PML itself. PML is subject to extensive regulation at transcriptional, post-transcriptional, and post-translational levels. Many of these modes of regulation depend on the cellular context and the presence of extracellular signals. This review focuses on the current knowledge of regulation of PML under normal cellular conditions as well as the role for regulation of PML in viral infection and cancer.

原文English
頁(從 - 到)366-376
頁數11
期刊International Journal of Biological Sciences
5
發行號4
DOIs
出版狀態Published - 2009

All Science Journal Classification (ASJC) codes

  • 生態學、進化論、行為學與系統學
  • 應用微生物與生物技術
  • 分子生物學
  • 發展生物學
  • 細胞生物學

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