TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity

Kuan Ru Chen, Chun Hung Chang, Ching Yu Huang, Chun Yang Lin, Wan Ying Lin, Yin Chiu Lo, Chia Yu Yang, En Wei Hsing, Lin Fang Chen, Shin Ru Shih, Ai Li Shiau, Huan Yao Lei, Tse Hua Tan, Pin Ling

研究成果: Article

14 引文 斯高帕斯(Scopus)

摘要

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key RNA viral sensors for triggering antiviral immunity. The underlying mechanisms for RLRs to trigger antiviral immunity have yet to be explored. Here we report the identification of TAPE (TBK1-associated protein in endolysosomes) as a novel regulator of the RLR pathways. TAPE functionally and physically interacts with RIG-I, MDA5, and IPS-1 to activate the IFN-β promoter. TAPE knockdown impairs IFN-β activation induced by RLRs but not IPS-1. TAPE-deficient cells are defective in cytokine production upon RLR ligand stimulation. During RNA virus infection, TAPE knockdown or deficiency diminishes cytokine production and antiviral responses. Our data demonstrate a critical role for TAPE in linking RLRs to antiviral immunity.

原文English
頁(從 - 到)32216-32221
頁數6
期刊Journal of Biological Chemistry
287
發行號38
DOIs
出版狀態Published - 2012 九月 14

    指紋

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

引用此

Chen, K. R., Chang, C. H., Huang, C. Y., Lin, C. Y., Lin, W. Y., Lo, Y. C., Yang, C. Y., Hsing, E. W., Chen, L. F., Shih, S. R., Shiau, A. L., Lei, H. Y., Tan, T. H., & Ling, P. (2012). TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. Journal of Biological Chemistry, 287(38), 32216-32221. https://doi.org/10.1074/jbc.C112.394346