Tendon gradient mineralization for tendon to bone interface integration

Jin Qu, Andrew R. Thoreson, Qingshan Chen, Kai Nan An, Peter C. Amadio, Chunfeng Zhao

研究成果: Article同行評審

16 引文 斯高帕斯(Scopus)

摘要

Tendon-to-bone integration is a great challenge for tendon or ligament reconstruction regardless of use of autograft or allograft tendons. We mineralized the tendon, thus transforming the tendon-to-bone into a "bone-to-bone" interface for healing. Sixty dog flexor digitorum profundus (FDP) tendons were divided randomly into five groups: (1) normal FDP tendon, (2) CaP (non-extraction and mineralization without fetuin), (3) CaPEXT (Extraction by Na2HPO4 and mineralization without fetuin), (4) CaPFetuin (non-extraction and mineralization with fetuin), and (5) CaPEXTFetuin (extraction and mineralization with fetuin). The calcium and phosphate content significantly increased in tendons treated with combination of extraction and fetuin compared to the other treatments. Histology also revealed a dense mineral deposition throughout the tendon outer layers and penetrated into the tendon to a depth of 200 μm in a graded manner. Compressive moduli were significantly lower in the four mineralized groups compared with normal control group. No significant differences in maximum failure strength or stiffness were found in the suture pull-out test among all groups. Mineralization of tendon alters the interface from tendon to bone into mineralized tendon to bone, which may facilitate tendon-to-bone junction healing following tendon or ligament reconstruction.

原文English
頁(從 - 到)1713-1719
頁數7
期刊Journal of Orthopaedic Research
31
發行號11
DOIs
出版狀態Published - 2013 十一月

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

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