TY - JOUR
T1 - Tendon injury produces changes in SSCT and nerve physiology similar to carpal tunnel syndrome in an in vivo rabbit model
AU - Moriya, Tamami
AU - Zhao, Chunfeng
AU - Cha, Stephen S.
AU - Schmelzer, James D.
AU - Low, Phillip A.
AU - An, Kai Nan
AU - Amadio, Peter C.
N1 - Funding Information:
Acknowledgments This study was funded by a grant from NIH (NIAMS AR 49823). The authors sincerely thank Ramona L. Kirk for her assistance with animal care.
PY - 2011/12
Y1 - 2011/12
N2 - Background: The etiology of carpal tunnel syndrome (CTS) remains idiopathic in many cases. Noninflammatory fibrosis of the subsynovial connective tissue (SSCT) within the carpal tunnel is common in CTS, and some clinicians have hypothesized that this fibrosis might be a cause rather than an effect of CTS. An animal model in which to test this hypothesis would be useful. The principal objective of this study was to investigate the effect of a surgical injury on SSCT fibrosis and median nerve function within the carpal tunnel in an in vivo rabbit model. Methods: Rabbits were sacrificed 12 weeks after surgery and were evaluated by mechanical testing, histology, transmission and scanning electron microscopy, and electrophysiology. Results: SSCT fibroblast density (p<0.0001) and collagen fiber size (p=0.0004) were significantly higher, and the median nerve distal motor amplitude was significantly lower (p=0.0018), in the tendon injury group SSCT than in either the sham or control groups. Conclusions: Our findings are similar to those seen in patients with carpal tunnel syndrome and suggest that the tendon injury procedure may be the basis of a new animal model of SSCT injury and, possibly, CTS.
AB - Background: The etiology of carpal tunnel syndrome (CTS) remains idiopathic in many cases. Noninflammatory fibrosis of the subsynovial connective tissue (SSCT) within the carpal tunnel is common in CTS, and some clinicians have hypothesized that this fibrosis might be a cause rather than an effect of CTS. An animal model in which to test this hypothesis would be useful. The principal objective of this study was to investigate the effect of a surgical injury on SSCT fibrosis and median nerve function within the carpal tunnel in an in vivo rabbit model. Methods: Rabbits were sacrificed 12 weeks after surgery and were evaluated by mechanical testing, histology, transmission and scanning electron microscopy, and electrophysiology. Results: SSCT fibroblast density (p<0.0001) and collagen fiber size (p=0.0004) were significantly higher, and the median nerve distal motor amplitude was significantly lower (p=0.0018), in the tendon injury group SSCT than in either the sham or control groups. Conclusions: Our findings are similar to those seen in patients with carpal tunnel syndrome and suggest that the tendon injury procedure may be the basis of a new animal model of SSCT injury and, possibly, CTS.
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U2 - 10.1007/s11552-011-9356-2
DO - 10.1007/s11552-011-9356-2
M3 - Article
C2 - 23204967
AN - SCOPUS:80855132775
SN - 1558-9447
VL - 6
SP - 399
EP - 407
JO - Hand
JF - Hand
IS - 4
ER -