Testing for efficacy in adaptive clinical trials with enrichment

Samuel S. Wu, Yi Hsuan Tu, Ying He

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Adaptive design of clinical trials has attracted considerable interest because of its potential of reducing costs and saving time in the clinical development process. In this paper, we consider the problem of assessing the effectiveness of a test treatment over a control by a two-arm randomized clinical trial in a potentially heterogenous patient population. In particular, we study enrichment designs that use accumulating data from a clinical trial to adaptively determine patient subpopulation in which the treatment effect is eventually assessed. A hypothesis testing procedure and a lower confidence limit are presented for the treatment effect in the selected patient subgroups. The performances of the new methods are compared with existing approaches through a simulation study.

原文English
頁(從 - 到)2736-2745
頁數10
期刊Statistics in Medicine
33
發行號16
DOIs
出版狀態Published - 2014 七月 20

All Science Journal Classification (ASJC) codes

  • 流行病學
  • 統計與概率

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