Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Po Wu Gean

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

原文English
頁(從 - 到)325-327
頁數3
期刊Brain Research Bulletin
37
發行號3
DOIs
出版狀態Published - 1995

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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