Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Su Jane Wang; Chiung Chun Huang; Po Wu Gean

doi:10.1016/0361-9230(95)00010-C

Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Po Wu Gean

藥理學科暨藥理學研究所

研究成果: Article › 同行評審

7 引文斯高帕斯（Scopus）

摘要

The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

原文	English
頁（從 - 到）	325-327
頁數	3
期刊	Brain Research Bulletin
卷	37
發行號	3
DOIs	https://doi.org/10.1016/0361-9230(95)00010-C
出版狀態	Published - 1995

All Science Journal Classification (ASJC) codes

神經科學 (全部)

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10.1016/0361-9230(95)00010-C

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title = "Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala",

abstract = "The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.",

author = "Wang, {Su Jane} and Huang, {Chiung Chun} and Gean, {Po Wu}",

note = "Funding Information: This study was supported by the National Science Council of Taiwan, Republic of China (NSC83-0412-B006-068).",

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T1 - Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

AU - Wang, Su Jane

AU - Huang, Chiung Chun

AU - Gean, Po Wu

N1 - Funding Information: This study was supported by the National Science Council of Taiwan, Republic of China (NSC83-0412-B006-068).

PY - 1995

Y1 - 1995

N2 - The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

AB - The effect of the centrally active anticholinesterase inhibitor Terahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by α-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

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ER -

Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

摘要

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