The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes

Jinghui Luo, Sebastian K.T.S. Wärmländer, Chien Hung Yu, Kamran Muhammad, Astrid Gräslund, Jan Pieter Abrahams

研究成果: Article同行評審

30 引文 斯高帕斯(Scopus)

摘要

Carbon nanotubes have specific properties that make them potentially useful in biomedicine and biotechnology. However, carbon nanotubes may themselves be toxic, making it imperative to understand how carbon nanotubes interact with biomolecules such as proteins. Here, we used NMR, CD, and ThT/fluorescence spectroscopy together with AFM imaging to study pH-dependent molecular interactions between single walled carbon nanotubes (SWNTs) and the amyloid-beta (Aβ) peptide. The aggregation of the Aβ peptide, first into oligomers and later into amyloid fibrils, is considered to be the toxic mechanism behind Alzheimer's disease. We found that SWNTs direct the Aβ peptides to form a new class of β-sheet-rich yet non-amyloid fibrils.

原文English
頁(從 - 到)6720-6726
頁數7
期刊Nanoscale
6
發行號12
DOIs
出版狀態Published - 2014 六月 21

All Science Journal Classification (ASJC) codes

  • 材料科學(全部)

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