Objective: Growing evidence shows that sleep restriction leads to insulin resistance and impaired glucose tolerance (IGT), and previous studies find an association between insomnia and IGT. However, there is little research evaluating the association between sleep quality and IGT. Therefore, the aim of this study is to investigate this relationship in a Chinese population. Methods: The data were collected from the decoded database from the Prevention Health Center of National Cheng Kung University Hospital from 2002 to 2006. The diagnoses of IGT and diabetes were according to the recommendations of the American Diabetes Association. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Results: A total of 1785 subjects with normal glucose tolerance (NGT), IGT and diabetes were recruited. The global PSQI scores were 6.08 ± 2.43, 6.73 ± 3.41 and 7.28 ± 3.42 in subjects with NGT, IGT and diabetes, respectively. Multivariate linear regression analysis showed that female gender, IGT, diabetes and smoking were independent determinants of global PSQI score. Conclusions: Subjects with IGT and diabetes had higher global PSQI scores than those with NGT. Furthermore, female gender, IGT, diabetes and smoking were significantly associated with global PSQI score independent of cardiometabolic risk factors in a Chinese population.
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