The association between the level of plasma oxytocin and craving among former heroin users

Shih Hsien Lin, Po See Chen, Lan Ting Lee, Sheng Yu Lee, Hsin Chun Tsai, Wei Tseng Chen, Kao Chin Chen, I. Hui Lee, Ru Band Lu, Yen Kuang Yang

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)


Background: Animal studies have demonstrated that oxytocin can influence addiction behaviors and might interact with the dopaminergic system, which is a key component of addiction behaviors. However, related evidence from clinical studies is scarce. The aim of our study was to explore the relationship between plasma oxytocin level and heroin craving among patients receiving methadone maintenance treatment, and to ascertain whether this relationship is moderated by novelty-seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan. Seventy-seven patients with heroin addiction were enrolled. Plasma oxytocin was measured using an ELISA kit. Craving was assessed using an established instrument, the Chinese Craving Scale. Results: A significant negative association was found between the plasma oxytocin level and craving score, which remained robust after controlling the effects of social support and low-density lipoprotein cholesterol. An interaction between oxytocin and novelty-seeking indicated that this relationship was stronger among patients with a lower level of novelty-seeking. Conclusion: This finding may be taken into account in future studies and may provide a basis for the development of potential treatment for addiction. The effect of oxytocin for the treatment of opioid dependence might be modulated by some psychological factors.

頁(從 - 到)71-78
期刊European Addiction Research
出版狀態Published - 2018 7月 1

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 健康(社會科學)
  • 精神病學和心理健康


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