The association of a cystatin C gene polymorphism with late-onset Alzheimer's disease and vascular dementia

C. Lin, S. T. Wang, C. W. Wu, L. J. Chuo, Yu Min Kuo

研究成果: Article同行評審

19 引文 斯高帕斯(Scopus)

摘要

A polymorphism in the cystatin C (CST3) gene was suggested to associate with Alzheimer's disease (AD). In the present study we attempted to determine the association between CST3 polymorphism and AD or vascular dementia (VD), and whether such effects are dependent of the APOE4 allele. The polymorphisms of CST3 genotype were determined using polymerase chain reactions (PCR) followed by gel electrophoresis in 124 AD, 70 VD, and 115 control individuals. No statistical difference in CST3B allele frequencies was observed among all three groups. Associations between CST3B/B genotype and AD patients older than 75-year-old, or VD patients younger than 75-year-old were evident. The APOE4 allele alone significantly increased the odds for the developing AD, but not VD. A logistic regression analysis revealed that either CST3 or its interaction with APOE4 were not significant predictors of AD. However, a synergistic association of CST3 and APOE4 alleles was observed in predicting VD patients. These results suggest that CST3 might interact with APOE4 on conferring vascular pathologies.

原文English
頁(從 - 到)111-115
頁數5
期刊Chinese Journal of Physiology
46
發行號3
出版狀態Published - 2003 九月 30

All Science Journal Classification (ASJC) codes

  • 生理學
  • 生理學(醫學)

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