The Binding of Abrin and Ricin by Ehrlich Ascites Tumor Cells

Jung Yaw Lin, Shyr Te Ju, Hua Lin Wu, Ta Cheng Tung

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Abrin and ricin cause 50% agglutination of Ehrlich ascites tumor cells (5*106/ml) at a concentration of 8 and 4 μg/ml, respectively. Addition of D-galactose or its derivatives, lactose or raffinose, inhibits the agglutinating activity of the toxic proteins. Binding of 13 I-toxic proteins on the tumor cells was shown to be specific, pH dependent, and concentration dependent. Native ricin, abrin, D-galactose, and its sterically related saccharides inhibit this specific binding, while concanavalin A, bovine serum albumin, heat-denatured abrin or ricin, and other saccharides do not. In the presence of D-galactose, the inhibition of protein biosynthesis by ricin does not occur in vitro.

原文English
頁(從 - 到)2688-2691
頁數4
期刊Cancer Research
33
發行號11
出版狀態Published - 1973 十一月

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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