The binding of plasminogen fragments to cultured human umbilical vein endothelial cells

Hua Lin Wu, Ing Shiang Wu, Ro Yun Fang, Jen Shau Hau, Dung Ho Wu, Bi Ing Cheng, Tsun Mei Lin, Guey Yueh Shi

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

Glu-plasminogen, kringle 1-5, kringle 1-3; and miniplasminogen exhibited strong binding to human umbilical vein endothelial cells (HUVEC). On the other hand, no significant binding was obtained with microplasminogen and kringle 4. Kringle 1-5 and miniplasminogen, which both contained kringle 5, specifically inhibited the binding of plasminogen to HUVEC while kringle 1-3 did not. The results implied plasminogen molecule contained at least two binding sites, with which it interacted HUVEC. The stronger binding site was located in kringle 5 and the weaker one was in kringle 1-3. Kringle 4 and the active site domain exhibited no significant binding to HUVEC. The interaction of plasminogen with HUVEC is mainly through binding site on kringle 5.

原文English
頁(從 - 到)703-711
頁數9
期刊Biochemical and Biophysical Research Communications
188
發行號2
DOIs
出版狀態Published - 1992 十月 30

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物化學
  • 分子生物學
  • 細胞生物學

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