The Chang Gung Research Database: Multi-institutional real-world data source for traditional Chinese medicine in Taiwan

Shih Chieh Shao, Edward Chia Cheng Lai, Tse Hung Huang, Ming Jui Hung, Ming Shao Tsai, Yao Hsu Yang, Yuk Ying Chan

研究成果: Article同行評審

摘要

Background: The Chang Gung Research Database (CGRD), the largest multi-institutional electronic medical records collection in Taiwan, has been used to establish real-world evidence related to traditional Chinese medicine (TCM). We aimed to evaluate patient characteristics and representativeness of TCM patients in CGRD. Methods: We identified a cohort of patients who had TCM records both from CGRD and from Taiwan's National Health Insurance Database (NHIRD) during 2010–2015 to investigate the representativeness of CGRD for TCM uses. The NHIRD was considered as reference because it covers all medical claims from 99.9% of the entire Taiwanese population. We investigated the coverage rates of TCM patients within CGRD compared to NHIRD, and compared the characteristics of patients between CGRD and NHIRD including age, sex, and 15 health conditions. Results: We identified 71 002 average annual patients within the CGRD, which accounted for 1.1% of the patients from the NHIRD. The patients from CGRD were older than those from NHIRD (≥65: 16.6% vs. 9.9% for CGRD vs. NHIRD). The ratios of female over male patients were 1.7 vs. 1.5 for CGRD vs. NHIRD. We found higher patient coverage rates for patients with major comorbidities in CGRD, specifically for neoplasm (9.2%) and mental disorders (6.0%). The most frequently prescribed Chinese herbal medicines in CGRD included Jia-Wei-Xiao-Yao-San, Xiang-Sha-Liu-Jun-Zi-Tang and Gui-Lu-Er-Xian-Jiao. Conclusion: Higher patient coverage rates were found in CGRD for TCM patients with major comorbidities. Investigators should note possible selection bias since TCM patient disorders may be more severe in CGRD than in the NHIRD.

原文English
頁(從 - 到)652-660
頁數9
期刊Pharmacoepidemiology and drug safety
30
發行號5
DOIs
出版狀態Published - 2021 五月

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Pharmacology (medical)

指紋 深入研究「The Chang Gung Research Database: Multi-institutional real-world data source for traditional Chinese medicine in Taiwan」主題。共同形成了獨特的指紋。

引用此