The cholinergic deficit coincides with Aβ deposition at the earliest histopathologic stages of Alzheimer disease

Thomas G. Beach, Yu Min Kuo, Katharyn Spiegel, Mark R. Emmerling, Lucia I. Sue, Katrina Kokjohn, Alex E. Roher

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108 引文 斯高帕斯(Scopus)

摘要

Effective therapeutic intervention in Alzheimer disease (AD) will be most effective if it is directed at early events in the pathogenic sequence. The cholinergic deficit may be such an early event. In the present study, the brains of 26 subjects who had no history of cognitive loss and who were in early histopathologic stages of AD (average Braak stage less than II) were examined at autopsy to determine whether a cortical cholinergic decrement was associated with Aβ concentration or deposition. In the superior frontal and inferior temporal gyri, the choline acetyltransferase (ChAT) activity of plaque-containing cases was significantly decreased (p < 0.05, unpaired, two- tailed t-tests), measuring 70.9% and 79.5%, respectively, relative to plaque- free cases. In the inferior temporal gyms, Spearman's rank correlation analysis showed that ChAT activity had a significant inverse correlation with Aβ concentration (p = 0.075; r = -0.3552). The results indicate that the cholinergic deficit is established at an early histopathologic stage of AD, before the onset of clinical symptoms.

原文English
頁(從 - 到)308-313
頁數6
期刊Journal of Neuropathology and Experimental Neurology
59
發行號4
DOIs
出版狀態Published - 2000 四月

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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