The core antigen of hepatitis B virus as a carrier for immunogenic peptides

Kenneth Murray, Ai Li Shiau

研究成果: Review article同行評審

25 引文 斯高帕斯(Scopus)

摘要

The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multi-component vaccines.

原文English
頁(從 - 到)277-283
頁數7
期刊Biological Chemistry
380
發行號3
DOIs
出版狀態Published - 1999 三月

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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