The development of behavioral and neuronal activities of animal models with kindling-induced and spontaneous temporal lobe seizures

Yu Lin Wang, Yin Lin Chen, Yu Shin Huang, Sheng Fu Liang, Fu Zen Shaw

研究成果: Conference contribution

摘要

Epilepsy, in terms of the sudden and recurrent malfunction of brain caused by abnormal discharge, is called “seizure”. Recently, experiments on animal models have successfully demonstrated the better understanding of the excitability of neuronal networks in relation to the occurrence of seizures. In this work, the developments of behavioral and neuronal activities of kindling-induced and spontaneous temporal lobe epilepsy (TLE) in rats were investigated. Daily stimulation of the right-side amygdala was delivered to Wistar rats to induce TLE. Each kindling evokes the excited neuronal activities in the brain. The duration, spike density and amplitude of evoked discharges were increased during kindling procedure. With repeated 40 stimulations, the rats showed the progression from tonic seizures (stage-1,2) to generalized clonic- tonic convulsive seizures (stage-4,5). In a consequence, the daily stimulation causes the permanent brain function damage and three rats were successfully induced to have spontaneous TLE of seizure stage-2. The cortical neuronal activities exhibit high voltage rhythmic spike (HVRS) discharges oscillating in the rage of 9-11 Hz and 18-21 Hz (second harmonics). HVRS is characterized by a barrage of large spike discharge (80-400μV) with negative polarity. It was found that the inter-spike interval (ISI) between two negative spikes is positively correlated (r=0.9852) to the amplitude of former spike in a HVRS episode. A large amplitude spike was accompanied by a long ISI, while a small amplitude spike took place in group with a short ISI. The investigation on cortical epileptiform is practical to develop the on-line seizure detection algorithms. With integration of an electrical stimulator or drug delivery device, such a seizure warning system or a closed-loop seizure control device could enhance the patients’ life quality.

原文English
主出版物標題The 15th International Conference on Biomedical Engineering, ICBME 2013
編輯James Goh
發行者Springer Verlag
頁面199-202
頁數4
ISBN(電子)9783319029122
DOIs
出版狀態Published - 2014 一月 1
事件15th International Conference on Biomedical Engineering, ICBME 2013 - Singapore, Singapore
持續時間: 2013 十二月 42013 十二月 7

出版系列

名字IFMBE Proceedings
43
ISSN(列印)1680-0737

Other

Other15th International Conference on Biomedical Engineering, ICBME 2013
國家/地區Singapore
城市Singapore
期間13-12-0413-12-07

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 生物醫學工程

指紋

深入研究「The development of behavioral and neuronal activities of animal models with kindling-induced and spontaneous temporal lobe seizures」主題。共同形成了獨特的指紋。

引用此