The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy

F. Y. Cheng, C. H. Tsai, D. B. Shieh, J. S. Huang

研究成果: Conference contribution

摘要

Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.

原文English
主出版物標題Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016
編輯Matthew Laudon, Fiona Case, Fiona Case, Bart Romanowicz, Bart Romanowicz
發行者TechConnect
頁面148-151
頁數4
ISBN(電子)9780997511727
出版狀態Published - 2016
事件10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States
持續時間: 2016 5月 222016 5月 25

出版系列

名字Advanced Materials - TechConnect Briefs 2016
3

Other

Other10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
國家/地區United States
城市Washington
期間16-05-2216-05-25

All Science Journal Classification (ASJC) codes

  • 流體流動和轉移過程
  • 生物技術
  • 表面、塗料和薄膜
  • 燃料技術

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